Matrix as an Interstitial Transport System
نویسندگان
چکیده
منابع مشابه
Matrix as an interstitial transport system.
The extracellular matrix (ECM) is best known for its function as a structural scaffold for the tissue and more recently as a microenvironment to sequester growth factors and cytokines allowing for rapid and localized changes in their activity in the absence of new protein synthesis. In this review, we explore this and additional new aspects of ECM function in mediating cell-to-cell communicatio...
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1Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Recherche (GIGA-Cancer), University of Liège, Liège, Belgium; 2Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Vlaams Instituut voor Biotechnologie–KULeuven, Leuven, Belgium; 3Unit of Molecular Biology and Genetic Engineering, GIGA-Cancer, University of Liège, Liège, ...
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Lymphatic dysfunctions are associated with several human diseases, including lymphedema and metastatic spread of cancer. Although it is well recognized that lymphatic capillaries attach directly to interstitial matrix mainly composed of fibrillar type I collagen, the interactions occurring between lymphatics and their surrounding matrix have been overlooked. In this study, we demonstrate how ma...
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OBJECTIVE Substantial evidence implicates interstitial collagenases of the matrix metalloproteinase (MMP) family in plaque rupture and fatal thrombosis. Understanding the compensatory mechanisms that may influence the expression of these enzymes and their functions, therefore, has important clinical implications. This study assessed in mice the relative effect of the 2 principal mouse collagena...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2014
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.114.302335